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Overall, preclinical and phase 1 data support that the primary mechanism for weight reduction by tirzepatide is regulation of appetite and decreases in food cravings and food intake, with increased lipid metabolism [76]
More data are needed to clarify the effects of GLP-1RAs on the incidence of OA, RA, PsA and axSpA, as well as on disease activity and progression in these conditions
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Bridge the metabolism-inflammation crossover in obesity and diabetes models Functional receptor-level data alongside cytokine profiling Is inflammasome activation involved
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