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Both moderate and significant reductions in BMI are associated with notable increases in serum testosterone levels, along with improvements in insulin sensitivity

[11] When speaking to your doctor, it may be helpful to: Be open about your weight management history , including previous dietary, behavioural, and pharmacological interventions Ask about clinical trial eligibility if you are interested in accessing investigational treatments through a regulated pathway Avoid self-prescribing or purchasing any injectable weight loss product online without medical supervision Discuss your expectations realistically , as no medication works in isolation lifestyle changes remain a cornerstone of sustainable weight management Healthcare professionals are best placed to provide personalised advice based on your medical history, current medications, and individual circumstances

Again, averages with wide individual variation

Food and Drug Administration, 2023