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Rosenstock noted that 37% of the orforglipron 36 mg group was able to reach an HbA1c of 5.7% or less at 1 year, a figure he described as amazing. We became familiar with tirzepatide [Mounjaro, Eli Lilly] with this concept of HbA1c of 5.7%, but this is impressive, Rosenstock said

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Its research profile makes it especially relevant for studies focused on metabolic flexibility, mitochondrial energy output, exercise-related signaling, cardiometabolic models, fatty acid utilization, and cellular energy demand

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The 52-week, phase 3 double-blinded RCT (PIONEER-4) directly compared the glycemic effects and body weight reduction of once-daily oral semaglutide (dose-escalated to 14 mg) and once-daily subcutaneous liraglutide (dose-escalated to 1.8 mg) among 711 T2D participants