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High Cost: These drugs are expensive and not easily accessible for the general population
Second, genetic variation in GLP1R expression and function means that some individuals experience maximal appetite suppression at lower doses, rendering further escalation unnecessary and potentially counterproductive
Split dosing maintains the higher exposure while reducing peaks, preserving the therapeutic benefit of the full dose
In clinical trials, semaglutide has demonstrated superior weight loss compared to older GLP-1 analogs, with an average loss of 15-20% of body weight
Phentermine's mechanism is fundamentally different
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