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Administered at a dose of 2.5 M, the drug had minimal effects on proliferating glioblastoma cells (LN229 and A172) while demonstrating significant senolytic properties against the same cell lines subjected to senescence induction by temozolomide [106]
Costs range from $2,000 to $5,000
This relationship remains consistent across formulationswhether compounded or brandedand is critical for dose tracking, prescription accuracy, and communication with healthcare providers
More serious but rare adverse effects include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), acute kidney injury (particularly with dehydration), and hypersensitivity reactions including anaphylaxis
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