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During these processes, optimal enzyme activity depends on essential cofactors (e.g., copper, zinc), and their reduced activity signals increased OS, and compromised antioxidant defense (153157)

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Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen peroxide, and reactive nitrogen species, such as nitric oxide, peroxynitrite, and nitrite, play a major role in the airway inflammation and are determinants of asthma severity

have found that NAD + directly regulates protein-protein interactions