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Kynurenine, a metabolite of tryptophan, upregulates T-cell PD-1 levels by inducing and activating the aryl hydrocarbon receptor (AhR), while AhR upregulates transporters to promote T cells to uptake kynurenine, forming a positive feedback loop and inhibiting anti-tumor immune responses (Liu et al., 2018)
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J Med Chem
Residual surface expression was determined from peptide- vs
It is designed to mimic melanocyte-stimulating hormone (MSH), a natural hormone that influences melanin production in the skin
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