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Baseline assessment Before starting tirzepatide, consider a baseline abdominal ultrasound if you have any of these risk factors: Female sex plus age over 40 BMI over 40 Family history of gallstones History of rapid weight cycling Hispanic or Native American ethnicity History of biliary symptoms A baseline ultrasound establishes whether stones are already present before treatment begins

This can become a cycle that continues even after you stop taking these medications, so putting a stop to muscle loss and tissue breakdown is an urgent task