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The trade-off is pharmacokinetic: oral delivery subjects the peptide to stomach acid (pH roughly 1.5-2.0 fasting) and proteolytic enzymes including pepsin and pancreatic proteases before any absorption can occur

The move from injectables to solid oral dose reflects a broader shift toward medicines that are easier to use, easier to scale and better suited to long-term patient needs

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It lists fasting insulin and HOMA-IR among the baseline measures that give context for that pattern

At 52 weeks, Foundayo lowered A1C by 1.9 percent at 9 mg and 2.2 percent at 17.2 mg, compared with 1.1 percent and 1.4 percent reductions for oral semaglutide 7 mg and 14 mg, respectively