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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione
A Phase 2 cagrilintide trial and later Phase 3 CagriSema research support the idea that amylin can add to GLP-1-based research
Consistent with this, pulmonary glutathione levels also display marked circadian variation, suggesting tight circadian control of this antioxidant pathway (59)
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