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Benefits of Semaglutide in Oral vs
Diabetes 38: 338-342, 1989
FTO , GLP1R (the GLP-1 receptor gene and direct drug target), MC4R (central to satiety), and TCF7L2 (linked to glucose homeostasis and GLP-1 secretion) map the metabolic terrain any GLP-1 compound works within
doi: 10.3390/molecules28031447
Specifically, GLP-1RA administration downregulated the protein expression of haptoglobin, upregulated levels of PRKC apoptosis WT1 regulator (PAWR) and of synapsis-related proteins including synapsin-1, phosphodiesterase-2A (PDE2A), dihydropyrimidinase-like 2 (DPYSL2), neurofibromin-1, and microtubule-associated protein 1B (MAP1B), and increased neuronal and synaptic densities [59]
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