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5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage

Pregnant and breastfeeding women must take this medicine only with a valid prescription

not FDA-approved for any indication

Conclusion: Fecal carriage of MDROs may play a role in modifying the gut microbiota and associated metabolites in cirrhosis, potentially contributing to the development of HE in those with MDRO carriage