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The porcupine plot revealed an interesting pattern of dynamics between the head and leg regions of the v3 integrin, in which the ligand-binding site containing the -propeller and I domains made inward motion toward the calf-2 domain of the leg region, possibly transmitting the activation signal directly to the leg region attached to the transmembrane tail
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DelaleuJGrynberg-LaloumEMogueletPHamannPFrancsCBarbaudAet al
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