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General Subcutaneous Injection Process Clean the injection area with an alcohol swab and allow to dry completely Draw the appropriate dose into an insulin syringe (29-31 gauge, 0.5 inch needle) Pinch a fold of skin and subcutaneous tissue between thumb and forefinger Insert the needle at a 45-degree angle into the pinched skin fold Release the skin fold and inject slowly over 5-10 seconds Withdraw needle and apply gentle pressure with a cotton ball if needed Do not rub or massage the injection site Wrist-Specific Injection Sites Local injection near the injury delivers higher peptide concentrations to target tissue compared to distant systemic injection

Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Victoria RawLast updated 12 May 2025 DownloadDownload Share Language Discussion Audio Version Add to preferred sources on Google Weight loss injections have been used by celebrities like Amy Schumer, Meghan Trainor, and Rebel Wilson - but are they really an option for everyone

Colloquially, these changes are referred to on social media as semaglutide face or Ozempic face, based on the commercial names of semaglutide

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