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NO might be expected to dilate blood vessels directly by relaxing capillary pericytes or preventing them constricting 9 , but this would be expected to occur even in the absence of GLP-1 receptor activation, predicting a constriction when L-NAME is applied, which is not seen in Fig
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These higher doses are where the most significant weight loss tends to occur in clinical trials
The trade-offs: more preparation steps, requires reconstitution knowledge for lyophilized formulations, and slightly more room for user error in dose measurement
Chang SN, Keretsu S, Kang SC
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