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Conversely, no causal link between T2DM and MDD was found in the same studies, supported by other data from a Scottish cohort [61]
In these cells, the transcription factor FOXO4 is highly upregulated and physically sequesters the tumor suppressor p53 in nuclear foci, preventing p53 from triggering apoptosis
Mol Aspects Med 25:551567
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Future studies should prioritize early PsA populations, ideally using stratified designs that incorporate metabolic profiling, to fully elucidate the dual immunomodulatory and metabolic potential of GLP-1RAs in altering disease trajectory
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