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Nausea is the most common side effect, affecting 20 to 44% of users across GLP-1 medications per FDA prescribing information for Wegovy, Zepbound, and Ozempic

Ipamorelin operates through a completely different pathway

Fertility and reproductive health Improved metabolic health can increase fertility, particularly for individuals with insulin resistance or PCOS

Indirect anti-inflammatory effects likely result from the metabolic improvements these medications produce

Furthermore, it is possible that somatostatin directly inhibits glucagon secretion by binding to its receptor in the alpha cell, since GLP- 1 stimulates islet somatostatin secretion directly through the canonical GLP- 1 receptor, expressed on delta cells [71]