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Common side effects include nausea, diarrhea and constipation, which typically subside as the body adjusts to the medication." Laura Buford, MD Importantly, GLP-1 medications only temporarily affect gastric emptying while you are actively taking them
Mechanistically, the NF-kB and cytokine effects should theoretically help, but lupus pathogenesis involves pathways (particularly type I interferon and complement activation) that may not be as responsive to GLP-1 signaling
10.3389/fmicb.2017.01725 6 BuT.SunZ.PanY.DengX.YuanG
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Weight loss can help mitigate these complications, but losing weight through diet and exercise alone can prove challenging
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