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They physically disrupt the electron transport chain, the series of protein complexes inside the mitochondria that generate ATP, leading to a catastrophic drop in cellular energy production

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This action reflects our responsibility to protect patients and preserve the integrity of the drug approval process while continuing to provide a transparent, science-based pathway for public input. Regulators are accepting public comments through June 29 to exclude semaglutide, tirzepatide and liraglutide, before any final change to the list of whats approved under 503B is made

1 2 European Food Safety Authority (25 September 2008)