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Struggle with severe digestive problems like gastroparesis since GLP-1s slow down digestion and could make symptoms worse
No completed Phase 2 or Phase 3 human trials have been published
Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22
This finding holds particular importance given no medications currently target both alcohol reduction and smoking cessation simultaneously
Everyones talking about GLP-1s
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