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The compound simultaneously activates three receptors that have historically been engaged separately or in pairs: GLP-1R (Glucagon-Like Peptide-1 Receptor)
However, this same mechanism may contribute to gastrointestinal side effects, which are among the most commonly reported adverse reactions with GLP-1 therapy
Thats why theyre used not only for managing type 2 diabetes, but also for weight loss in people with obesity or overweight
EN designed the study
Adding semaglutide to an already sensitive GI tract can be particularly challenging
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