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Quitting it can lead to regaining much of the weight you lost
With ADH off, the kidney collecting ducts retract the water channel proteins that would normally allow water reabsorption, so the kidneys release large volumes of dilute, pale urine
NPJ Biofilms Microbiomes 11 , 218 (2025)
There is a flip side, however
Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, though these medications are often collectively referred to as incretin-based therapies
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