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3.1% for placebo (Jastreboff et al., NEJM 2022)

Patients with retinopathy or uncontrolled blood sugars that could lead to retinopathy are not candidates for Semaglutide

The triple-agonist hypothesis predicts that GIP receptor activation, by enhancing insulin secretion and improving glycemic control, will offset the hyperglycemic effects of glucagon receptor activation while preserving its energy-expenditure benefits

This may be because: They cant be made in advance since theyre only stable for a short period of time The medication is made from a combination of ingredients that are not cost-effective or practical to submit to Health Canada for approval, the way most prescription medications are

The specifics depend on the plan but may require additional paperwork from the prescribing healthcare provider or a process called step therapytrying other, often less expensive, drugs first