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eClinicalMedicine 57 , 101865 (2023)
Pharmaceutical companies are intensifying R&D investments to optimize oral GLP-1 efficacy and expand indication approvals
Tirzepatide has a higher affinity with GLP-1R than GLP-1 does (pIC 50 : 8.90 vs 8.62), and its cAMP activation activity is significantly lower (12 decrease in pEC 50 )
You start low to let your body adjust, and then step up to higher strengths
The source of this claim has not been published in a peer-reviewed journal
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