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Cell culture studies have investigated glutathione's interactions with tyrosinase, the rate-limiting enzyme in melanin synthesis, examining how reduced glutathione shifts melanocyte pigment production pathways at the biochemical level

While AOD-9604 does not stimulate cell proliferation (no IGF-1 elevation), the precautionary principle applies for active malignancies

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The most commonly reported side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

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