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Dysfunctional adipose tissue promotes increased cardiovascular and diabetes disease risk via multiple pathways including increased free fatty acids (FFA) in the liver, infiltration of visceral fat deposits by proinflammatory macrophages resulting in chronic low-grade inflammation, and reduced buffering capacity for protective lipid storage [7]
Appetite hormones such as ghrelin rise, fullness hormones such as leptin fall, and metabolism slows slightly to conserve energy
R.NauckM
This pathway has been confirmed in multiple in vitro studies and in animal models
Presented for research literature review only Imanaka M et al
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