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What Are the Side Effects of Melanotan I

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Biochim Biophys Acta Mol basis Dis

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A distinctive off-target effect of Melanotan-2 is mast cell activation and histamine release via MRGPRB2-dependent mechanisms, producing transient hypothermia and flushing independent of melanocortin receptor signaling

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These effects are generally mild to moderate in severity and tend to diminish over time as patients develop tolerance ^1

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