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Many insurance plans do cover GLP-1 medications for the treatment of type 2 diabetes and obesity, but coverage may be limited for certain medications or patient populations
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Enzymatic Cofactor Activity : Serves as an essential cofactor for glutathione peroxidase and glutathione reductase enzymes, enabling these protective systems to neutralize hydrogen peroxide and lipid peroxides that would otherwise damage cellular membranes
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In February 2017, the European Medicines Agency (EMA) issued a warning concerning increased risk of lower limb amputation (especially toes) related to SGLT2 inhibitor therapy, although this risk was demonstrated to be significant only for canaglifozin [105]
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