Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
By blocking NNMT, 5-Amino 1MQ disrupts the enzymes role in metabolism and energy homeostasis, presenting a unique opportunity to study these processes in detail
Clinical trials involving over 900 participants showed AOD-9604 to be well-tolerated with side effects indistinguishable from placebo in most studies
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