step 1 trial semaglutide 2.4 mg weight loss nejm 2021 2·4 once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 Semaglutide in Patients with Heart

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Clinical trials have demonstrated significant efficacy, with patients losing approximately 15% of body weight with semaglutide 2.4 mg (STEP 1 trial) and up to 20% with tirzepatide (SURMOUNT-1 trial) when combined with lifestyle modifications

Do I have to follow a diet for this to work

According to the findings, losing 5.1 kg of weight was associated with a -4.44 mm Hg systolic and -3.57 mm Hg DBP drop

Semaglutide has a long half-life of approximately one week, meaning it takes around four to five weeks after your last injection for the medication to be mostly cleared from your body through natural metabolic processes