Pathways for Intracellular Signaling in the Langerhans Islets GLP- 1 receptor, GIP receptor, and glucagon receptor are mainly expressed on beta, alpha, and delta cells in the islets of Langerhans, where they influence hormone secretion and regulate the survival and proliferation of endocrine cells
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Results Human 3D microtissues (MTs) of a maturing cardiac model and a mature hepatic model were exposed to culture medium with or without 0.1% DMSO for two weeks with sampling time points at 2, 8, 72, 168, 240 and 336 hours
Group 2 samples were immediately fixed in 4% paraformaldehyde and then embedded in paraffin for immunohistochemical analysis