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Medications and Supplements Certain substances act as blood thinners, making you much more likely to bruise from even a tiny needle prick
Refrigerate unused GLP-1/GIP medication (36F to 46F [2C to 8C]), but not near the cooling element
The pipeline continues to expand: Novo Nordisk filed an NDA for CagriSema (semaglutide + cagrilintide) in December 2025, which achieved 22.7% weight loss in the REDEFINE 1 trial, and Eli Lilly reported Phase 3 results for retatrutide , a triple GIP/GLP-1/glucagon agonist that delivered 28.7% weight loss
In some cases, alternative treatments with fewer metabolic effects might be appropriate, or the timing of therapies could be optimised to minimise conflicting effects whilst maintaining therapeutic benefit
What varies between providers: The depth of the medical evaluation differs significantly
