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A 2026 review in eClinicalMedicine looked at the full body of GLP-1 stop studies
How do GLP-1 medications work
One of the most concrete changes: rapid weight loss consumes lean muscle mass
The Wegovy prescribing information states explicitly: "Discontinue WEGOVY at least 2 months before a planned pregnancy" because of the long half-life of semaglutide (approximately 7 days, requiring roughly 5 half-lives for washout) [3]
Patients with inherited metabolic disorders affecting fatty acid oxidation
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