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Clinical trials show that Ozempic leads to substantially greater weight reduction, while metformin typically results in more modest weight loss
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Early evidence suggests it is generally well-tolerated, with most side effects being mild to moderate gastrointestinal symptoms (such as nausea, diarrhoea, or constipation)
Generic and biosimilar semaglutide: what's actually in the pipeline As of April 2026, the FDA has received zero Abbreviated New Drug Applications (ANDAs) for generic semaglutide
On the policy side, the Medicare GLP-1 Bridge program took effect July 1, lowering copays for eligible Part D beneficiaries to $50 per month through 2027 a structural tailwind for the entire obesity treatment category
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