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ABSTRACT KEY FIGURE Highlights INTRODUCTION DISCOVERY OF GLP-1 AND DEVELOPMENT OF INCRETIN-BASED DRUGS GLP-1 AND IMPLICATIONS IN COGNITIVE SATIATION: HUMAN STUDIES HYPOTHALAMIC FUNCTIONS IN COGNITIVE FEED-FORWARD REGULATION HYPOTHALAMIC CONTROL OF GLP-1 ACTIONS ON SATIATION AND SATIETY: ANIMAL STUDIES ONGOING FUTURE STUDIES OF GLP-1R AGONISTS NOTES REFERENCES About this article ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as blockbuster drugs for treating metabolic diseases

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Nature Reviews Endocrinology: The effects of growth hormone on adipose tissue: old observations, new mechanisms Multidisciplinary Digital Publishing Institute: Central Regulation of Metabolism by Growth Hormone Medical Anti-Aging: Sermorelin Medical Evidence Journal of Anti-Aging Medicine: Growth Hormone Releasing Hormone Treatment in Normal Aging Translational Andrology and Urology: Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males Springer Nature Link: Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis

Medical studies back these reports, revealing that the drugs mechanism, which involves altering digestive processes, may contribute to these complications