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The claimant suffered from excessive vomiting requiring medication, her teeth falling out because of the vomiting, stomach pain, gastrointestinal burning, and hospitalization multiple times from stomach issues related to the drugs
This mechanism represents a control of the influx of fatty acyl units into mitochondria in response to the intra-mitochondrial acetyl-CoA level, in addition to the finely regulated mechanism of CPT1 by malonyl-CoA
Addiction Biology , 18(4), 628-638
(235) tested the sensitivity of 117 cancer cell lines to Erastin-induced ferroptosis and found that diffuse large B-cell lymphoma and clear cell renal cell carcinoma (ccRCC) were particularly sensitive to GPX4-regulated ferroptosis
