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IGF-1 + SARMs (e.g., RAD-140, LGD-4033) A mild post-cycle protocol is recommended: DHEA 100 mg/day for 4 weeks ZMT Hormonal support and cortisol regulation Optional: Over-the-counter aromatase inhibitors if experiencing estrogen-related side effects For more on hormonal changes when stopping support compounds, read What Happens When You Stop Taking DHEA

Pivotal Phase 3 trials Trial SURMOUNT-1 (NEJM 2022) Population 2,539 adults, obesity, no diabetes