Sampietro M, Lupica L, Perrero L, Comino A, Martinez di Montemuros F, Cappellini MD et al
Yes, if you take oral progestogen as part of HRT
Fernndez-Carrasco M, Snchez Garca O, Plaza Fernndez A (2024) Acquired chronic hepatocerebral degeneration (CAHD) Simulation of parkinsonism, secondary to chronic liver disease
doi: 10.3389/fimmu.2022.845974 77 LiGGCaoYHRunYXuRXZhengZD
Potential long-term effects associated with regular use include: Needing increasing doses to achieve the same effect Cognitive difficulties, including memory and attention problems Mood disturbances such as depression and anxiety Sleep disruption and chronic daytime fatigue Sexual dysfunction or reduced libido Social, occupational, and legal consequences related to use patterns The likelihood and severity of these effects vary across individuals based on frequency of use, dose, co-occurring mental health conditions, and other factors