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Persistent diarrhea may require pharmacologic intervention with loperamide (Imodium) at 2 mg after the first loose stool, then 2 mg after each subsequent episode, up to 16 mg daily
While an increase in metformin exposure was observed, it was not considered clinically relevant by the investigators
Daily dosing applies only to the activation phase in weeks 14
MOTS-C: Mitochondrial-Derived Peptide Research Guide MOTS-C is a short peptide encoded within mitochondrial DNA
Physician supervision is what changes the outcome
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