The clinical impact of this effect varies between individuals, and while studies of subcutaneous GLP-1 receptor agonists have generally been reassuring, caution is still advised, particularly as levothyroxine has a narrow therapeutic index
Patient safety issues in the GLP-1 space this week Reddit, September 2, 2025 (Click the image to enlarge it) Although online searches turn up many businesses selling what they call GLP-1 drops for people who wish to avoid injections, there is no evidence that these products contain GLP-1s or that they would be effective if they did
Moreover, recently it has been reported that the pathway governed by NE2FL2 is not only regulated by the proteasome but also by ATG (Jain et al., 2013)
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