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The primary outcome was all-cause mortality
That said, there are biologically plausible indirect pathways by which semaglutide treatmentespecially when accompanied by rapid appetite suppression, gastrointestinal adverse effects, and clinically meaningful weight losscould unmask or exacerbate pre-existing vaginal symptoms (for example, genitourinary syndrome of menopause) or contribute to discomfort through dehydration, altered sex steroid milieu, or pelvic soft-tissue volume changes
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Pre-existing nutrient deficiencies
Andrew Huberman And I went back and forth on this literature because I thought, "No, water would be better." But they compared water, two liters a day or a liter or more per day of diet soda, and it seems like it's a pretty good weight loss tool for people that would otherwise be drinking soda, or would otherwise be drinking just water, which really surprised me
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