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Activation in the area postrema (AP) The area postrema is a circumventricular organ , a region of the brain that has no blood-brain barrier , so peptide hormones from the blood have direct access to it
Beyond collagen, GHK-Cus effects on the extracellular matrix extend to elastin (30% increase), decorin (302% increase at 1 nanomolar concentration), glycosaminoglycans, dermatan sulfate, and chondroitin sulfate
PDRN (polydeoxyribonucleotide) activates dermal adenosine A2A receptors to drive fibroblast activity, angiogenesis, and anti-melanogenesis
Inflammation likely plays a part in several of these effects, but the exact biology in humans is still not well understood
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