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Persistent spreading redness, heat, purulent drainage, or fever above 100.4F are not normal side effects and require medical evaluation for possible infection

Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability

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They work through different mechanisms: phentermine is a sympathomimetic that suppresses appetite via norepinephrine release

B 14 , 12831301 (2024)