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Through the analysis of numerous in vivo and in vitro studies aimed at determining the mechanisms by which GLP-1 enhances insulin secretion in individuals with normal glucose tolerance or T2DM, two main intracellular mechanisms underlying the incretin effect have emerged
10.1016/j.pharmthera.2021.108044 34 LuttrellL
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The full effect builds over 36 months as doses are gradually increased
Rather than opposing dopamine directly, they promote satiety, modifying the context in which dopaminergic learning occurs
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