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Previous work [89] has shown that glucose acutely stimulates a sharp increase in the NADPH:NADP + ratio concomitant with insulin secretion

they recruit cAMP response element-binding protein (CREB)-binding protein (CBP) or receptor-associated coactivator 3 (RAC3), to facilitate the transactivation of NRF2 target genes [146, 147]

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It works primarily by increasing VEGF expression (which promotes new blood vessel growth at injury sites) and activating cell adhesion pathways that speed tissue repair

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