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Some of the most clinically relevant findings: 12.7% mean weight loss at 12 months, with nearly 60% of patients achieving 10% weight loss 18.9% reduction in total fat mass, including continuous visceral fat reduction Although lean mass decreased initially (as expected during weight loss), it stabilized after 7 months Muscle strength improved significantly (+4.1 kg handgrip strength), highlighting that muscle function can be preservedand even enhanceddespite reductions in lean mass Sarcopenic obesity prevalence decreased from 49% to 33% Resting energy expenditure normalized for lean mass increased between months 7 and 12, suggesting improved metabolic efficiency Why does this matter

These drugs are glucagon-like peptide-1 (GLP-1) receptor agonists that can make you feel less hungry and feel full sooner

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Spironolactone (50 mg/kg, once a day for 6 weeks, oral administration) can reduce diabetes-related vascular oxidative stress and prevent vascular dysfunction by increasing the expression of antioxidant enzymes and soluble guanidyl cyclase (sGC) [4]