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found that PA (100 mgkg-1) attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c, TNF-, IL-6 and IL-1, and mechanistically, PA might suppress liver lipid accumulation and inflammation by regulating MMP8 (Li et al., 2024)

These are fats that accumulates in and around organs, including the liver

The increased PEP also inhibited phosphofructose kinase (encoding by pfk ) activity, which was responsible for the decreased glycolytic flux and the down regulation of the glycolytic activities [33]

The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption