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A recent retrospective case series which is a type of research which looks back on a group of people who have already been diagnosed or treated for a particular condition reported on 47 subjects who had been selected and definitely diagnosed with MCAS

Inflammation causes weight gain

Funct Integr Genomics 24:220

Adding a medication that suppresses appetite further limits oral intake and nutrient acquisition on top of that

In a rigorously conducted phase 3 study, exenatide failed to improve motor symptoms in Parkinsons disease, reminding the field that mechanistic plausibility does not always translate into clinical efficacy