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GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)

Chronic Dis Transl Med

Digestive effects that can dehydrate GLP-1s often slow digestion, resulting in side effects like nausea, vomiting, or diarrhea/constipation

3.3.1 Efficacy of GLP-1 RAs on liver characteristics in MASLD Among the 24 meta-analyses, 12 reviews investigated the effect of GLP-1 RAs on HFC in MASLD, four examined histologic resolution, and one studied FIB-4 (Supplementary Tables S5, S6)