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Furthermore, congenital heart defects (CHD) are found in almost a half of DS births, and increasing evidence points to a possible contribution of lack of folic acid supplementation at peri-conception, maternal polymorphisms of folate pathway genes, and resulting epigenetic modifications of several genes, at the basis of their occurrence

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This concept is known as bioavailability, which refers to the proportion of a nutrient that enters the circulation and is able to have an active effect

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